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KMID : 0061119840120000159
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Bulletin of the Clinical Research Institute
1984 Volume.12 No. 0 p.159 ~ p.159
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Effects of Vitamin A on Wound Burst Strength and Body Wight in Cyclophosphanmid Treated Rats
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Chung, Sang-Hun
Ahn, Sang-Tae/Kim, Jin-Chul/Lim, Poong
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Abstract
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Cyclophosphamide lays restraints upon production of fibroblast and collagen fiber and reduce wound burst strength in acute inflammatory phase. On the contrary, vitamin A is known to increase inflammatory reaction´ by exerting an effect upon inflammatory cells in the beginning of the wound healing process.
In order to study the influence of vitamin A on wound healing delay induced by cyclophosphamide in rats, we observed and compared the wound burst strength of cyclophosphamide with vitamin A combined treated group with those of control and cyclophosphamide treated group.
Results of the experiment. were as follows;
1. Wound burst strength in control group increased slowly as days went by and showed trends of sudden increase between the 5th and 7th postoperative days.
2. Wound burst strength in cyclophosphamide treated group was markedly decreased than that in control group.
3. Wound burst strength in cyclophosphamide with vitamin A combined treated group was similar to that in control group.
4. Body weight in cyclophosphamide treated group was reduced gradually as days went by. But there´s no significant weight change in cyclophosphamide with vitamin A combined treated group.
Judging from these results, vitamin A can prevent or recuperate the side effects of cyclophosphamide, delay of wound healing and worsening of general condition.
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